Universitätsklinikum des Saarlandes, Klinik für Innere Medizin III, Homburg (Saar), Germany. Electronic address: michael.boehm@uks.eu. Robertson Centre for Biostatistics, University of Glasgow, Glasgow, United Kingdom. Division of Cardiovascular Medicine, The Howard Gilman Institute for Heart Valve Disease and the Schiavone Institute for Cardiovascular Translational Research, State University of New York Downstate Medical Center, New York, New York. Institute of Cardiometabolism and Nutrition, Pierre et Marie Curie Paris VI University, La Pitié-Salpétrière Hospital, Paris, France. Universitätsklinikum des Saarlandes, Klinik für Innere Medizin III, Homburg (Saar), Germany. Department of Cardiology, General Hospital Celje, Celje, Slovenia. Department of Molecular and Clinical Medicine, Sahlgrenska Academy, University of Gothenburg, Göteborg, Sweden. Maria Cecilia Hospital, Gruppo Villa Maria (GVM) Care and Research, Ettore Sansavini Health Science Foundation, Cotignola, Italy.